Player Draft
| Name | State | School | Class | Pos. | Year | Round | Team |
| Davis Schwab | KS | Blue Valley West | 2015 | LHP | 2019 | 37 | Braves |
| JT Schwartz | CA | Corona del Mar | 2018 | 1B | 2021 | 4 | NYM |
| Brent Schwarz | CO | Regis Jesuit | 2015 | RHP | 2015 | 39 | Rockies |
| Tyler Schweitzer | IN | Hamilton Southeastern | 2019 | LHP | 2022 | 5 | White Sox |
| Spencer Schwellenbach | MI | Saginaw Heritage | 2018 | SS | 2021 | 2 | Atlanta Braves |
| Seth Schwindenhammer | IL | Limestone | 2009 | OF | 2009 | 5 | Red Sox |
| Connor Scott | FL | Plant | 2018 | OF | 2018 | 1st | Miami Marlins |
| Wesley Scott | CA | Woodcrest Christian | 2019 | RHP | 2022 | 8 | Royals |
| Victor Scott | GA | McEachern | 2019 | OF | 2022 | 5 | Cardinals |
| Matt Scott | CT | Joel Barlow | 2022 | RHP | 2022 | 20 | Rangers |
| Kyle Scott | MD | Manchester Valley | 2020 | RHP | 2023 | 15 | Guardians |
| Andre Scrubb | VA | Hylton | 2013 | RHP | 2016 | 8th | Dodgers |
| Jacob Scudder | IL | Rock Island | 2013 | C | 2017 | 16 | Nationals |
| Ben Sears | RI | East Providence | 2018 | SS | 2022 | 14 | Royals |
| Brett Sears | IA | Harlan | 2019 | RHP | 2024 | 7 | Braves |
| Andrew Sears | RI | West Warwick | 2020 | LHP | 2023 | 10 | Tigers |
| Chad Sedio | OH | Highland | 2012 | OF | 2016 | 27 | Tigers |
| Cody Sedlock | IL | Rock Island Alleman | 2013 | RHP | 2016 | 1 | Orioles |
| Quintin Sefcik | IL | Carmel Catholic | 2014 | RHP | 2019 | 24 | Reds |
| Billy Seidl | MA | St. Sebastians | 2019 | RHP | 2022 | 15 | White Sox |
| Hayden Seig | PA | Mechanicsburg Area | 2016 | RHP | 2021 | Free Agent | Los Angeles Angels |
| Anthony Seigler | GA | Cartersville | 2018 | C | 2018 | 1st | Yankees |
| Blake Seigler | SC | North Augusta | 2017 | RHP | 2021 | Free Agent | Los Angeles Angels |
| Chris Seise | FL | West Orange | 2017 | SS | 2017 | 1 | Rangers |
| Colin Selby | VA | Western Branch | 2015 | RHP | 2018 | 16 | Pirates |
| Shane Selman | LA | Barbe | 2015 | OF | 2019 | 21st | Athletics |
| Brock Selvidge | AZ | Hamilton | 2021 | LHP | 2021 | 3 | New York Yankees |
| Eric Senior | ON | York Mills Collegiate | 2015 | OF | 2017 | 13 | Nationals |
| Eli Serrano | NC | Pro5 Academy | 2022 | OF | 2024 | 4 | Mets |
| Barrett Serrato | IL | West Chicago | 2008 | SS | 2012 | 30 | Rangers |
| Danny Serretti | NJ | Governor Livingston | 2018 | SS | 2022 | 6 | Tigers |
| Chris Serritella | IL | Loyola | 2008 | 1B | 2012 | 4 | Phillies |
| Peter Serruto | NJ | Millburn | 2018 | C | 2018 | 22 | Cincinatti Reds |
| Adam Serwinowski | SC | Eastside | 2022 | LHP | 2022 | 15 | Reds |
| Robert Sexton | OH | Watkins Memorial | 2012 | LHP | 2016 | 14 | Red Sox |
| Bobby Seymour | IL | Mount Carmel | 2017 | 1B | 2021 | 13 | Tampa Bay Rays |
| Colby Shade | CO | Fort Collins | 2020 | OF | 2023 | 9 | Marlins |
| Teddy Sharkey | NJ | Wall | 2020 | RHP | 2023 | 7 | Orioles |
| Sterling Sharp | MI | North Farmington | 2013 | RHP | 2016 | 22 | Nationals |
| Brian Sharp | MO | Liberty North | 2015 | C | 2018 | 26 | Mets |
| Reese Sharp | IN | University | 2019 | RHP | 2022 | 20 | Orioles |
| Jacob Sharp | CA | La Mirada | 2020 | C | 2023 | 17 | Mariners |
| Chris Sharpe | MA | Bridgton | 2015 | OF | 2017 | 14 | Pirates |
| Davis Sharpe | GA | Mill Creek | 2018 | RHP | 2018 | 34th | Pirates |
| AJ Shaver | FL | South Lake | 2020 | OF | 2023 | 17 | Phillies |
| Matthew Shaw | MA | Worcester Academy | 2020 | SS | 2023 | 1 | Cubs |
| Sam Shaw | BC | Lambrick Park | 2023 | SS | 2023 | 9 | Blue Jays |
| Evan Shawver | OH | Amherst Steele | 2018 | LHP | 2021 | 7 | Colorado Rockies |
| Ben Sheckler | MI | Cornerstone | 2013 | LHP | 2016 | 8 | Padres |
| George Emmet Sheehan | CT | Salisbury School | 2018 | RHP | 2021 | 6 | Los Angeles Dodgers |
| Grant Shepardson | CO | Mountain Vista | 2024 | RHP | 2024 | 5 | Marlins |
| Austin Shields | ON | St. Mary's Catholic Secondary School | 2016 | RHP | 2016 | 33 | Pirates |
| David Shields | PA | Mt. Lebanon | 2024 | LHP | 2024 | 2 | Royals |
| Luke Shilling | MI | Notre Dame Prep | 2015 | RHP | 2015 | 20 | Rangers |
| Wooyeoul Shin | JUCO | South Korea | 2020 | 2B | 2023 | 16 | Rays |
| Jaxon Shirley | IN | Lapel | 2016 | 3B | 2016 | 34 | White Sox |
| Luke Shliger | NY | Trinity Pawling | 2020 | C | 2023 | 6 | Giants |
| Adam Shoemaker | ON | St. Benedict | 2021 | LHP | 2021 | 11 | Atlanta Braves |
| Kodey Shojinaga | HI | Mid-Pacific Institute | 2022 | 2B | 2024 | 6 | Phillies |
| Avery Short | IN | Southport | 2019 | LHP | 2019 | 12 | Diamondbacks |
| Zack Showalter | FL | Wesley Chapel | 2022 | RHP | 2022 | 11 | Orioles |
| Darren Shred | ON | St. Roch Catholic | 2015 | C | 2015 | 22 | Reds |
| Dalton Shuffield | TX | Johnson | 2017 | SS | 2022 | 10 | Twins |
| Nick Shumpert | CO | Highlands Ranch | 2015 | SS | 2016 | 28 | Braves |
| Mike Siani | PA | William Penn Charter | 2018 | OF | 2018 | 4 | Reds |
| Sam Siani | PA | William Penn Charter | 2019 | OF | 2019 | Comp. Balance A | Pirates |
| TJ Sikkema | IA | Central Dewitt | 2016 | LHP | 2019 | 38th Overall Pi | Yankees |
| Easton Sikorski | MI | De La Salle Collegiate | 2018 | RHP | 2022 | 17 | Reds |
| William Silva | FL | Miami Coral Park | 2019 | RHP | 2022 | 15 | Braves |
| Eric Silva | CA | JSerra | 2021 | RHP | 2021 | 4 | SF |
| Anthony Silvas | CA | Moreno Valley | 2021 | RHP | 2023 | 16 | Twins |
| Kevin Sim | CA | Torrey Pines | 2020 | 3B | 2023 | 5 | Diamondbacks |
| Karson Simas | CA | Clovis West | 2019 | SS | 2019 | 26 | Red Sox |
| Cameron Simmons | PA | Spring-Ford | 2015 | OF | 2019 | 20 | White Sox |
| Dylan Simmons | FL | Trinity Christian Academy | 2019 | RHP | 2023 | 15 | Reds |
| Kendall Logan Simmons | GA | Tattnall Square Academy | 2018 | SS | 0 | 6 | P |
| Liam Simon | NJ | Freehold Township | 2019 | RHP | 2022 | 5 | Giants |
| Benjamin Simon | NJ | Hightstown | 2020 | RHP | 2023 | 13 | Mets |
| Anthony Simonelli | VA | Millbrook | 2017 | RHP | 2021 | 16 | Royals |
| Jared Simpson | IA | Clinton | 2018 | LHP | 2023 | 8 | Nationals |
| Chandler Simpson | GA | St. Pius X Catholic | 2019 | 2B | 2022 | CBB | Rays |
| Will Simpson | WA | Skyline | 2019 | 1B | 2023 | 15 | Athletics |
| Demetrius Sims | MI | Ann Arbor Huron | 2013 | SS | 2017 | 14 | Marlins |
| Jacob Sims | ON | Bishop Mac | 2015 | C | 2018 | 31 | San Diego Padres |
| Landon Sims | GA | South Forsyth | 2019 | RHP | 2022 | CBA | Diamondbacks |
| Brady Singer | FL | Eustis | 2015 | RHP | 2015 | 2 | Blue Jays |
| Luke Sinnard | TN | Beech | 2021 | RHP | 2024 | 3 | Braves |
| Michael Sirota | CT | The Gunnery | 2021 | OF | 2024 | 3 | Reds |
| Brandyn Sittinger | OH | Keystone | 2012 | RHP | 2016 | 17 | Tigers |
| Kyle Skeels | PA | Neshaminy | 2015 | C | 2019 | 36 | Cardinals |
| Ethan Skender | IL | Metamora | 2015 | SS | 2016 | 28 | Padres |
| Paul Skenes | CA | El Toro | 2020 | RHP | 2023 | 1 | PIT |
| Carson Skipper | AL | Hewitt Trussville | 2018 | LHP | 2022 | 11 | Rockies |
| Evan Skoug | IL | Libertyville | 2014 | C | 2017 | 7 | White Sox |
| Johnny Slater | MI | Southfield-Lathrup | 2013 | OF | 2017 | 28 | Mariners |
| Jake Slaughter | LA | Ouachita Christian | 2016 | SS | 2018 | 18th | Cubs |
| Ryan Sloan | IL | York | 2024 | RHP | 2024 | 2 | Mariners |
| Ethan Sloan | CO | Cherokee Trail | 2020 | OF | 2024 | 8 | Tigers |
| Ryan Sloniger | PA | Punxsutawney Area | 2015 | C | 2019 | 38 | Blue Jays |
| Jackson Smeltz | IN | McCutcheon | 2018 | LHP | 2022 | 10 | Padres |