Player Draft
| Name | State | School | Class | Pos. | Year | Round | Team |
| Joe Sanchez | FL | Terra Environmental Research Institute | 2017 | LHP | 2017 | 39 | Braves |
| Justin Sanchez | NY | Monsignor McClancy | 2022 | LHP | 2022 | 18 | Rangers |
| Cameron Sanders | LA | E.D. White | 2015 | RHP | 2018 | 12th | Cubs |
| Will Sanders | GA | Woodward Academy | 2020 | RHP | 2023 | 4 | Cubs |
| Travis Sanders | TX | Copperas Cove | 2022 | SS | 2022 | 14 | Red Sox |
| David Sandlin | OK | Owasso | 2019 | RHP | 2022 | 11 | Royals |
| Jayvien Sandridge | PA | Mercersburg Academy | 2018 | LHP | 2018 | 32 | Orioles |
| John Sansone | PA | Neshannock | 2012 | SS | 2016 | 8 | Reds |
| Christian Santana | FL | American Heritage | 2017 | RHP | 2017 | 15 | Brewers |
| Andres Santana | FL | Doral Academy Charter | 2017 | OF | 2017 | 29 | Astros |
| Adrian Santana | FL | Doral Academy | 2023 | SS | 2023 | 1-A | Rays |
| Benito Santiago | FL | Coral Springs Christian Academy | 2014 | C | 2014 | 38 | Giants |
| Chris Santiago | CA | De La Salle | 2019 | 3B | 2022 | 18 | Mets |
| Alex Santos | NY | Mount St. Michael Academy | 2020 | RHP | 2020 | 2 | Houston Astros |
| Nolan Santos | FL | Miami Beach | 2019 | RHP | 2023 | 7 | Twins |
| Jamie Sara | VA | West Potomac | 2016 | RHP | 2019 | 25th | Phillies |
| Kelena Sauer | HI | Kamehameha | 2020 | RHP | 2023 | 15 | Blue Jays |
| Eli Saul | BC | Prince of Wales | 2019 | RHP | 2022 | 13 | Diamondbacks |
| Grayson Saunier | TN | Collierville | 2022 | RHP | 2022 | 19 | Rangers |
| Jason Savacool | NY | Baldwinsville | 2020 | RHP | 2023 | 6 | Cardinals |
| Jon Savarise | IL | Stevenson | 2012 | LHP | 2012 | 33 | White Sox |
| Dan Savas | IL | Leyden | 2010 | RHP | 2014 | 19 | Diamondbacks |
| Nate Savino | VA | Potomac Falls | 2020 | LHP | 2022 | 3 | Diamondbacks |
| Alec Sayre | OH | Dover | 2019 | OF | 2022 | 17 | Twins |
| Nate Scantlin | KS | Rose Hill | 2017 | OF | 0 | 15 | Reds |
| Caden Scarborough | FL | Harmony | 2023 | RHP | 2023 | 6 | Texas Rangers |
| Brandon Schaeffer | PA | Schuylkill Haven | 2018 | LHP | 2022 | 18 | Mariners |
| Reid Schaller | IN | Lebanon | 2016 | RHP | 2018 | 3 | Nationals |
| Brady Schanuel | IL | Belleville East | 2015 | RHP | 2017 | 20 | Phillies |
| Nolan Schanuel | FL | Park Vista | 2020 | OF | 2023 | 1 | Angels |
| Zach Schellenger | PA | Devon Prep | 2014 | RHP | 2017 | 6 | Red Sox |
| Garrett Schilling | MI | Bishop Foley | 2014 | RHP | 2017 | 18 | Rockies |
| Luke Schiltz | FL | Stoneman Douglas | 2019 | RHP | 2019 | 24th | Texas Rangers |
| Dylan Schlaegel | TX | Mansfield Legacy | 2023 | OF | 2023 | 17 | Red Sox |
| Tyler Schlaffer | IL | Homewood-Flossmoor | 2019 | RHP | 2019 | 9 | Cubs |
| Garrett Schlecht | IL | Waterloo | 2011 | LHP | 2011 | 9 | Cubs |
| Jacob Schlesener | MO | Logan-Rogersville | 2015 | LHP | 2015 | 12 | Cardinals |
| Cam Schlittler | MA | Walpole | 2019 | RHP | 2022 | 7 | Yankees |
| Ryan Schlosser | MN | South St. Paul | 2014 | RHP | 2016 | 32 | Braves |
| Matt Schmidt | CO | Regis Jesuit | 2015 | 3B | 2015 | 37 | Yankees |
| Davis Schneider | NJ | Eastern Regional | 2017 | 3B | 2017 | 28 | Toronto Blue Jays |
| Nicholas Schnell | IN | Roncalli | 2018 | OF | 2018 | 1 | Rays |
| Aaron Schnurbush | MO | Eureka | 2012 | LHP | 2016 | 28 | White Sox |
| Tanner Schobel | VA | Walsingham Academy | 2020 | SS | 2022 | CBB | Twins |
| Garrett Schoenle | IN | Northrop | 2017 | LHP | 2021 | Free Agent | White Sox |
| Cole Schoenwetter | CA | San Marcos | 2023 | RHP | 2023 | 4 | Reds |
| Tyler Schoff | NY | Rome Free Academy | 2017 | RHP | 2021 | Free Agent | Washington Nationals |
| Tyrell (TJ) Schofield-Sam | ON | North Park | 2019 | 3B | 2019 | 12 | Oakland Athletics |
| Jake Schrand | OH | Colerain | 2017 | RHP | 2021 | 9 | Miami Marlins |
| RJ Schreck | CA | Harvard Westlake | 2018 | OF | 2023 | 9 | Mariners |
| Troy Schreffler | PA | Central Dauphin | 2019 | OF | 2022 | 15 | Phillies |
| Scott Schreiber | WI | Kimberly | 2014 | RHP | 2018 | 9 | Astros |
| John Schreiber | MI | Rockwood | 2013 | RHP | 2016 | 15 | Tigers |
| Hunter Schryver | PA | Cumberland Valley | 2013 | LHP | 2017 | 7 | Rays |
| Austin Schulfer | WI | Stevens Point | 2014 | RHP | 2018 | 19 | Twins |
| Thomas Schultz | PA | Mount Carmel Area | 2019 | RHP | 2023 | 9 | Nationals |
| Noah Schultz | IL | Oswego East | 2022 | LHP | 2022 | 1 | White Sox |
| Brett Schulze | MN | Maple Grove | 2016 | RHP | 2019 | 7 | Phillies |
| Davis Schwab | KS | Blue Valley West | 2015 | LHP | 2019 | 37 | Braves |
| JT Schwartz | CA | Corona del Mar | 2018 | 1B | 2021 | 4 | NYM |
| Brent Schwarz | CO | Regis Jesuit | 2015 | RHP | 2015 | 39 | Rockies |
| Tyler Schweitzer | IN | Hamilton Southeastern | 2019 | LHP | 2022 | 5 | White Sox |
| Spencer Schwellenbach | MI | Saginaw Heritage | 2018 | SS | 2021 | 2 | Atlanta Braves |
| Seth Schwindenhammer | IL | Limestone | 2009 | OF | 2009 | 5 | Red Sox |
| Connor Scott | FL | Plant | 2018 | OF | 2018 | 1st | Miami Marlins |
| Wesley Scott | CA | Woodcrest Christian | 2019 | RHP | 2022 | 8 | Royals |
| Victor Scott | GA | McEachern | 2019 | OF | 2022 | 5 | Cardinals |
| Matt Scott | CT | Joel Barlow | 2022 | RHP | 2022 | 20 | Rangers |
| Kyle Scott | MD | Manchester Valley | 2020 | RHP | 2023 | 15 | Guardians |
| Andre Scrubb | VA | Hylton | 2013 | RHP | 2016 | 8th | Dodgers |
| Jacob Scudder | IL | Rock Island | 2013 | C | 2017 | 16 | Nationals |
| Ben Sears | RI | East Providence | 2018 | SS | 2022 | 14 | Royals |
| Andrew Sears | RI | West Warwick | 2020 | LHP | 2023 | 10 | Tigers |
| Chad Sedio | OH | Highland | 2012 | OF | 2016 | 27 | Tigers |
| Cody Sedlock | IL | Rock Island Alleman | 2013 | RHP | 2016 | 1 | Orioles |
| Quintin Sefcik | IL | Carmel Catholic | 2014 | RHP | 2019 | 24 | Reds |
| Billy Seidl | MA | St. Sebastians | 2019 | RHP | 2022 | 15 | White Sox |
| Hayden Seig | PA | Mechanicsburg Area | 2016 | RHP | 2021 | Free Agent | Los Angeles Angels |
| Anthony Seigler | GA | Cartersville | 2018 | C | 2018 | 1st | Yankees |
| Blake Seigler | SC | North Augusta | 2017 | RHP | 2021 | Free Agent | Los Angeles Angels |
| Chris Seise | FL | West Orange | 2017 | SS | 2017 | 1 | Rangers |
| Colin Selby | VA | Western Branch | 2015 | RHP | 2018 | 16 | Pirates |
| Shane Selman | LA | Barbe | 2015 | OF | 2019 | 21st | Athletics |
| Brock Selvidge | AZ | Hamilton | 2021 | LHP | 2021 | 3 | New York Yankees |
| Eric Senior | ON | York Mills Collegiate | 2015 | OF | 2017 | 13 | Nationals |
| Barrett Serrato | IL | West Chicago | 2008 | SS | 2012 | 30 | Rangers |
| Danny Serretti | NJ | Governor Livingston | 2018 | SS | 2022 | 6 | Tigers |
| Chris Serritella | IL | Loyola | 2008 | 1B | 2012 | 4 | Phillies |
| Peter Serruto | NJ | Millburn | 2018 | C | 2018 | 22 | Cincinatti Reds |
| Adam Serwinowski | SC | Eastside | 2022 | LHP | 2022 | 15 | Reds |
| Robert Sexton | OH | Watkins Memorial | 2012 | LHP | 2016 | 14 | Red Sox |
| Bobby Seymour | IL | Mount Carmel | 2017 | 1B | 2021 | 13 | Tampa Bay Rays |
| Colby Shade | CO | Fort Collins | 2020 | OF | 2023 | 9 | Marlins |
| Teddy Sharkey | NJ | Wall | 2020 | RHP | 2023 | 7 | Orioles |
| Sterling Sharp | MI | North Farmington | 2013 | RHP | 2016 | 22 | Nationals |
| Brian Sharp | MO | Liberty North | 2015 | C | 2018 | 26 | Mets |
| Reese Sharp | IN | University | 2019 | RHP | 2022 | 20 | Orioles |
| Jacob Sharp | CA | La Mirada | 2020 | C | 2023 | 17 | Mariners |
| Chris Sharpe | MA | Bridgton | 2015 | OF | 2017 | 14 | Pirates |
| Davis Sharpe | GA | Mill Creek | 2018 | RHP | 2018 | 34th | Pirates |